Table 3 Adjusted and multiple testing-corrected circulating proteins associated with female sex
From: Sex differences in circulating proteins in heart failure with preserved ejection fraction
| Clinical model (AUC 0.82) | Proteins | |||
|---|---|---|---|---|
| OR (95% CI) for female sex association | p value | OR (95% CI) for female sex association | p value | |
| Heart rate, per 10 bpm increase | 1.22 (1.00–1.48) | 0.049 | ||
| Total cholesterol, per 10 mg/dL increase | 1.13 (1.03–1.02) | 0.010 | ||
| Smoking status | ||||
| Never | Ref. | – | ||
| Former | 0.21 (0.12–0.36) | < 0.001 | ||
| Current | 0.33 (0.14–0.80) | 0.014 | ||
| CAD | 0.36 (0.21–0.62) | < 0.001 | ||
| Previous HF hospitalization | 0.47 (0.27–0.82) | 0.008 | ||
| Hb, per 1 g/dL increase | 0.69 (0.57–0.82) | < 0.001 | ||
| Higher expression in females vs. males | ||||
| IL1RL2 | 4.13 (2.22–7.68) | < 0.001 | ||
| LPL | 4.08 (2.44–6.82) | < 0.001 | ||
| LHB | 3.15 (2.20–4.52) | < 0.001 | ||
| IGFBP3 | 2.83 (1.74–4.58) | < 0.001 | ||
| PLIN1 | 2.44 (1.62–3.66) | < 0.001 | ||
| Ep-CAM | 1.87 (1.41–2.48) | < 0.001 | ||
| Less expression in females vs. males | ||||
| NRP1 | 0.05 (0.01–0.19) | < 0.001 | ||
| MMP-3 | 0.22 (0.14–0.35) | < 0.001 | ||
| ACE2 | 0.41 (0.28–0.61) | < 0.001 | ||