Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies

Table 3 Significant functions in the functional meta-analyses. The logarithm of the odds ratio (LOR), its confidence interval (LOR-CI), the adjusted p value, and the group in which the function was overexpressed are shown (W, women; M, men)

	GO ID	Name	LOR	LOR-CI	Adj. p value	Group
Gene functional meta-analysis	GO:0001012	RNA polymerase II regulatory region DNA binding	0.132	[0.079, 0.185]	0.008	W
	GO:1900165	Negative regulation of interleukin-6 secretion	-0.762	[-1.088, -0.437]	0.018	M
	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	0.131	[0.073, 0.188]	0.02	W
	GO:0017166	Vinculin binding	0.511	[0.271, 0.75]	0.035	W
	GO:0071352	Cellular response to interleukin-2	0.467	[0.248, 0.687]	0.035	W
	GO:0090177	Establishment of planar polarity involved in neural tube closure	-0.514	[-0.748, -0.279]	0.035	M
	GO:0090178	Regulation of establishment of planar polarity involved in neural tube closure	-0.523	[-0.768, -0.279]	0.035	M
	GO:1901215	Negative regulation of neuron death	0.116	[0.06, 0.171]	0.043	W
	GO:0070669	Response to interleukin-2	0.446	[0.23, 0.662]	0.046	W
Pathway functional meta-analysis	GO:0098655	Cation transmembrane transport	0.194	[0.11, 0.279]	0.012	W
	GO:0030001	Metal ion transport	0.141	[0.074, 0.208]	0.027	W
	GO:1904062	Regulation of cation transmembrane transport	0.216	[0.119, 0.32]	0.027	W
	GO:0098662	Inorganic cation transmembrane transport	0.186	[0.093, 0.278]	0.038	W

ISSN: 2042-6410